Our New Oral Cytokine Formula is a True Game Changer

What are antlers and why do deer have them? | Wildlife Online



We are constantly pushing the envelope to come up with methods to improve our results clinically. We think that our new cytokine formula may be such a game changer. Our new formula makes use of Velvet Deer Antler. But the formula is much different from those formulas out there both in strength and the formula itself. It is a proprietary mix.



The above

illustration represents the growing portion of the antler. Deer Antler Velvet

has been used in traditional Chinese medicine for thousands of years but has recently

gained popularity in Western medicine. Deer antler can enhance immune system

function, improving athletic performance, increasing muscle recovery, enhance

sexual function, improve disease recovery, enhance cardiovascular function, and

a host of other conditions.




Antler Velvet covers the growing bone and cartilage that develops into deer

antlers. The growing antler

contains a number of necessary cells, including fibroblasts, chondroblasts,

chondrocytes and osteocytes. The tips of the antlers begin as undifferentiated

mesenchymal stem cells which are transformed into cartilage. Later, the

cartilage is turned to bone, due to the effects of testosterone. Deer antler

velvet is antler that is still in its cartilaginous stage


of the problems with Velvet Deer Antler is the purity and concentration of the

product. Our antler product is sourced from a very reliable source. Typically,

there is a concentration of 1500 mg of velvet extract per bottle. Honestly,

that will have some effects but it is not exactly what we are looking for. We

have sourced a concentration of 4500 mg of Velvet Deer Antler per bottle. This

concentration would not be legal for any professional athlete and thus we would

not use it on them. Typically, these higher concentrations will help balance

hormones and promote tissue repair. In addition to this we have actually added

certain supplements to this very potent formula. These supplements will

increase stem cell efficiency and output from the bone marrow. This combination

is totally unique to our practice and network and it is proprietary in








The Benefits of Deer Antler Velvet | ProBLEN




above diagram gives some idea of the many benefits of deer extract. An

important concept that is a common theme of many research papers is that the

combination of all components of velvet antler provides a synergistic effect

that is greater than the total effect that would be achieved by the separate

use of each of its individual constituents. That means that if velvet antler is

broken down into its constituents that are used separately, their combined

effect is significantly less than the effect realized when the nutrients are

provided in the naturally combined form of velvet antler. In summary, the

effect of the complete product is greater than the summed effect of all




Let us take a

better look at exactly what is found in the antler products. Most of the antler

product consists of protein. The active ingredients include collagen, lipids,

glycosaminoglycans, minerals, and various growth factors. We will take a look at the major subgroups of

components. The first component to take a look at are the glycosaminoglycans











are complex carbohydrates.

Glycosaminoglycans (GAGs), have widespread functions

within the body. GAGs play a critical role in Regenerative Medicine. They play

a crucial role in the cell signaling

process, including regulation of cell growth, proliferation, promotion of cell adhesion,

anticoagulation, and wound repair. They are an integral component of what is

called the extracellular matrix. The extracellular matrix (ECM) is the non-cellular

component present within all tissues and organs, and provides not only

essential physical scaffolding for the cellular constituents but also initiates

crucial biochemical and biomechanical cues that are required for tissue

morphogenesis, differentiation and homeostasis.







Research has

shown GAGs exist in velvet antler in several forms including:




Chondroitin Sulphate a carbohydrate that

helps protect and rebuild degenerating cartilage and is regarded as a potent

anti-inflammatory agent




Glycosphingolipids are compounds

involved with growth and metabolism of cells and with memory and learning




Glucosamine Sulphate is a component of

Chondroitin Sulphate and is a major component of cartilage and synovial fluid




Hyaluronic acid a substance that binds

cartilage cells together and lubricates joints. It also acts as a signaling

molecule in many biological processes.




Phospholipids the major structural lipid

of most cell membranes






Here is a good illustration of the ExtraCellular Matrix. It is the substance between the cells.






Research - Regentys




Antlers grow by endochondral

ossification, the same way that long bones do. A major non-collagenous protein,

proteoglycan, a protein substituted with glycosaminoglycan chains, occurs in

the cartilaginous tissue of antler. While its use in the antler is not

understood, it has been shown that proteoglycan in cartilage, also called

aggrecan, regulates differentiation of chondrocytes and may control calcium

concentration in the growth plates where endochondral ossification occurs. This

may have important implications when we are treating joints with regenerative







More importantly,

the next two illustrations show the ramifications of the ExtraCellular

Matrix and repair of various tissues. We can see why enhancing the ExtraCellular Matrix is so important in Regenerative Medicine. We can

see that these represent the pillars of regenerative cell therapy. There are

few if any other products which have these effects on the extracellular matrix.

This is certainly a huge benefit that comes with the Velvet Deer Antler




















Glycosaminoglycans have a hand in all of the above repair processes. Most

products are only addressing the cellular portions of repair while the antler

products are more comprehensive in their approach.




next illustration shows how the Glycosaminoglycans are involved in the new

field of tissue engineering. In the case of tissue engineering we call the

synthetic ECM a scaffold.



Biomolecules | Free Full-Text | Glycosaminoglycans in Tissue Engineering: A  Review | HTML








we look at velvet antler growth factors, we see a list of whos who in

the growth factor universe. Growth factors, which are generally considered

as a subset of cytokines, refer to the diffusible signaling proteins that

stimulate cell growth, differentiation, survival, inflammation, and tissue repair. The major

growth factors which are found in deer antler include Insulin Like growth

factors (IGF-1), Bone morphogenetic growth factors (BMPs), Transforming growth

factor family (TGF), Fibroblast growth factor (FGF), Platelet derived growth

factor (PDGF), Vascular endothelial growth factor (VEGF), Epidermal growth

factor (EGF), Interleukins, and a variety of other factors. When looking at the

various growth factors we realize that this appears to be similar to what is

found in a Platelet Rich Plasma (PRP) product, and for that matter stem cells

themselves release.





Another aspect of deer antler deals with

its Amino acid contents. Remember that amino acids are natures building blocks. Amino acids, often referred to as the

building blocks of proteins, are compounds that play many critical roles in

your body. They’re needed for vital processes like the building of proteins and

synthesis of hormones and neurotransmitters. These are broken down to essential and

non-essential amino acids. Another type of amino acid is the free form amino acid. These

amino acids aren’t joined together with any other amino acids in a

protein ‘string’. This allows the individual amino acids to be

instantly absorbed and used by the body without digestion. All of o



Of all the growth factors the most

consequential might be IGF-1. IGF-1 is a banned substance in the world of

professional sports. The precursor of IGF-1 is Human Growth Hormone (HGH).

IGF-1 is actually the active form of HGH. It is considered performance

enhancing. In the smaller doses this is typically not an issue but in the higher

doses we are using this is a problem and across the board we will not give this

formula to any athlete in the high school, college, or the professional sports

arena. Putting this aside, why do we like IGF-1? We can see some of the

benefits below.



Benefits of human growth hormone | Growth hormone, Hormone supplements,  Hormones




Perhaps more importantly, we need to look at

IGF-1 on the basis of cell biology. IGF-1 has been shown to enhance

the migratory response of stem cells. We must realize that the IGF-1 supplied

by deer antler is a natural form. It seems to be safer than taking the

synthetic anabolic agents which can have disastrous consequences to ones

health. The following diagram is somewhat complicated but we see the importance

of IGF-1. It will interact with the stem cell and cause the cell to go on to

repair tissue or differentiate into that tissue.




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and the other growth factors can also result in a number of other health

benefits. These extra health benefits may include preservation of a persons

muscle mass, improving the functioning of the immune system, increasing bone

density thus helping to improve Osteoporosis, a valid treatment for

fibromyalgia conditions, and lastly it may help in weight loss. The bottom line

is that these growth factors are all very important in treating damaged tissue.

This tissue could be a tendon, a joint, or muscle. Remember, with the antler we

are complimenting the growth factors that are supplied by the stem cells and

the Platelet Rich Plasma. Also, by taking these supplements on a daily basis we

continue the repair process. The one small caveat that we follow is that in

those patients who have a history of certain cancers we will typically

recommend a lower dose of the antler product. We should also keep in mind that

antler products also contain small amounts of the sex hormones testosterone and

estrogen. In the right doses these are also important for regeneration.




 Another related factor found in

the antler is Prostaglandins.

They are substances with varying physiologic effects, acting as a

vasodepressor, smooth muscle contraction or relaxation, inflammation and

uterine stimulation. As components of deer antler velvet, prostaglandins may

assist in the capacity of the extract to reduce the swelling associated with

arthritis and injury. They also have physiological responses in lipid

metabolism, as seen in the cholesterol-lowering effects of deer antler velvet

on laboratory animals.








antler contains many different types of amino acids. Amino acids, often

referred to as the building blocks of proteins, are compounds that play many

critical roles in your body. Amino acids are organic compounds composed of

nitrogen, carbon, hydrogen and oxygen, along with a variable side chain group.

Your body needs 20 different amino acids to grow and function properly. Though

all 20 of these are important for your health, only nine amino acids are

classified as essential. These are histidine, isoleucine, leucine, lysine,

methionine, phenylalanine, threonine, tryptophan, and valine. Unlike

nonessential amino acids, essential amino acids are those that cant be made by

your body and must be obtained through your diet. Another type of amino acid is

a Free-form amino acid. This

refers to single amino acid that is already in a pre-digested form and ready to

be used by your body. Some nutritional products, especially amino acid blends,

contain whole proteins and large peptides (chains of amino acids), which the

body must first break down into smaller peptides and individual amino acids

before use. For faster utilization and better bioavailability, look for

free-form amino acids. We can see that all the various different types of amino

acids work synergistically. They all have their purpose.









In addition to the Velvet Deer

Antler which provides all the aforementioned compounds. There are a host of

other compounds which enhance the efficacy of the product. These include a natural matrix of herbs bounded by research and science

to help ones stem cells become more active and body supportive. The following

compounds highlight these ingredients.





found in the cell walls of certain seaweed species that is has been used

medicinally for a wide variety of health purposes. Okinawa inhabitants have a diet rich in Wakame seaweed,

which contains the highest concentrations of Fucoidan. Okinawa is also known

for its high concentration of centenarians (people who are at least a century

old), which researchers believe is linked to their fucoidan-rich diet. The

anti-aging effects are associated with Fucoidan’s remarkable ability to

facilitate tissue regeneration, immune function as well as improving cell-to-

cell communication. Not only is fucoidan known for its anti-aging effects, it

is also believed to combat cancer, metabolic syndrome and other degenerative

disorders. With stem cell therapy, there is always the risk that the adult stem

cells could migrate to other areas of the body unintentionally. However, the

daily use of fucoidan has been proven to increase mobilization of stem cells to

the appropriate area/ site of injury. Not only can fucoidan point the stem

cells in the proper direction, it has also shown to improve the stem cells’

survival during the differentiation process.




 PTEROSTILBENE is a stilbene molecule and demethylated

derivative of resveratrol ( it is more bioavailable than resveratrol) that is

found in antioxidant-rich foods like blueberries, cranberries and grapes. These all help to slow down

the aging process. It is an antioxidant that helps fight free

radical damage.

It is known to stimulate a series of pathways in the body called Sirtuin gene

pathways. The sirtuin genes have effects on a variety of other pathways in the

body. Ultimately, the Sirtuins are involved in the regulation of the

mitochondria and subsequent ATP production. Research has shown Pterostilbene

protects against memory loss, high cholesterol, high blood

pressure levels

and even certain types of cancer.



CARNOSINE is an important nonessential amino acid

that helps support brain, heart, and eye health. It offers antioxidant

protection from free radicals and oxidative stress, boosts endurance, aids in

the recovery process, and offers electrolyte support.




the least known, but yet strongest anti-oxidants that insures chromosomes

retain their health and rebuild themselves to optimum health.

RHODIOLA  an adaptogenic herb that can elevate your mood and

mental stamina, reduce the stress hormone, cortisol and fight

depression due to its protective effects on key mood

neurotransmitters. Rhodiola rosea extracts have recently demonstrated its anti-aging,

anti-inflammation, immuno-stimulating, DNA repair and anti-cancer effects in

different model systems. An adaptogenic herb helps the body adapt

to and resist physical, chemical, and environmental stress.




 ASTRAGIN is a 100%

natural compound which is patented and promotes a healthy gut lining reducing

inflammation in the intestinal lining and increasing absorption of nutrients. AstraGin has the ability to increase the assimilation of

important amino acids which increase nitric oxide levels in the human body,

making it the perfect performance enhancer when taken

pre-workout.  Higher levels of nitric oxide result in enhanced blood

flow to the muscle which leads to better pumps, muscular contraction, and

improved nutrient transportation. AstraGin also aids in glucose absorption so

having this pre-workout ensures that you have sufficient energy levels whilst

you train.










 One could

have the absolute best formula on paper but the question is will it work? When

we evaluate medications and supplements a very important aspect to consider is

what we call the pharmacokinetics of the product. This concerns the science of

how the drug moves around in the body. Unfortunately, on paper many compounds

seem very promising but in real life are a failure. The main reason for this is

that they cannot be absorbed by the body.



The mode of

absorption of the antler product is what is referred to as sublingual. This

means it is absorbed under the tongue. This is many times a very effective mode

of absorption. It bypasses the gut and goes directly into the bloodstream where it is needed. The components are not broken down.

Also, in the saliva are very small particles called exosomes which can be

considered a rising star in drug delivery. Saliva is a very rich source of

exosomes. Thus, we have a very efficient method of delivering the velvet

components in a safe and reliable manner.



If we were to

undertake the task of trying to design a complete supplement to utilize in

Regenerative Medicine and Stem Cell therapy, Velvet Deer Antler would be at the

top of our list. It has most of the ingredients needed for success.

Furthermore, there is a very efficient way to deliver the goods to the cell

where they are needed. Deer antler will not be the only modality we will use,

but it certainly has an important place on our mantle. We are constantly

working to push the envelope and I suspect more advances will come.













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